منابع مشابه
Checking folding inside and out
In This Issue In This Issue he ER is a site of both synthesis and quality control. Rejected, improperly folded proteins are destroyed by a well-characterized machinery (the ER-associated degradation [ERAD] pathway) in the cytosol and ER membrane that extracts and chews up any unfolded proteins. But the mechanisms for recognizing unfolded proteins as targets for destruction are less well charact...
متن کاملInside Out
I have alwayswanted to be adoctor.Manyaspects ofmedicine enthralled me: research, diagnosis, and the possibility of improving a patient’s quality of life, in particular.Walking the corridors of a hospital felt exhilarating. At 15 I had a volunteer position at the local hospital. Although my assignments were answering phones, directing visitors, and, my favorite, delivering goods topatients, I f...
متن کاملSpoiling Inside and Out
peace accords signed between 1988 and 1998, thirty-one failed to last more than three years.1 Contributing to their failure was the behavior of so-called spoilers: those who use violence or other means to undermine negotiations in the expectation that a settlement will threaten their power or interests.2 The stakes for understanding spoiler behavior are high. Where parties kept spoilers at bay,...
متن کاملDystroglycan inside and out.
Dystroglycan connects the extracellular matrix and cytoskeleton. Key findings in the past year indicate that dystroglycan interacts with a wider repertoire of extracellular ligands than originally appreciated, that dystroglycan plays a critical role in organizing extracellular matrix molecules on the cell surface and in basement membranes, and that at least two human pathogens utilize dystrogly...
متن کاملFolding Rulers inside Triangles
An l-ruler is a chain of n links, each of length l. The links, which are allowed to cross, are modelled by line segments whose endpoints act as joints. A given connguration of an l-ruler is said to fold if it can be moved to a connguration in which all its links coincide. We show that l-rulers connned inside an equilateral triangle of side 1 exhibit the following surprising alternation property...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2004
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1651iti1